Focusing on the limitation of conventional static Functional Connectivity (FC) techniques in investigating the dynamic functional brain states, an effective method based on whole-brain Dynamic Functional Connectivity (DFC) was proposed to characterize the time-varying brain states. First, the Diffusion Tensor Imaging (DTI) data were used to construct individual whole-brain networks with high accuracy and the functional Magnetic Resonance Imaging (fMRI) data of motor-related task was projected to the corresponding DTI space to extract the fMRI signals of each node for each subject. Then, one kind of sliding time window approach was applied to calculate the time-varying whole-brain functional connectivity strength matrix, and the corresponding Dynamic Functional Connectivity Vector (DFCV) samples were further extracted and collected. Finally, the DFCV samples were learned and classified by one sparse representation based method called Fisher Discriminative Dictionary Learning (FDDL). Total eight different whole-brain functional connectome patterns representing the dynamic brain states were obtained from this motor-related task experiment. The spatial distributions of functional connectivity strength showed obvious variance within different patterns. The pattern #1, pattern #2 and pattern #3 covered most of the samples (77.6%) and the similarities between each of them and the average static whole-brain functional connectivity strength matrix were obviously higher than other five patterns. Furthermore, the brain states were found to transfer from one pattern to another according to certain rules. The experimental results show that the proposed analysis method combining whole-brain DFC and FDDL learning is effective for describing and characterizing the dynamic brain states during task brain activity. It provides a foundation for exploring the dynamic information processing mechanism of the brain.
A novel motion segmentation algorithm based on multi-model robust estimation was proprosed. Fisrtly, the split and merge technique based on quad-tree was proposed to obtain the initial motion numbers of robust estimation and corresponding initial parameters of motion model. Then the parameters were updated by using estimating parameters, and the motion models were merged based on the motion consistency. Lastly small motion objects could be detected by using small-object detection techniques. Experimental results show that the method can obtain promising results.